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The fold and active site of the Yeast Hypothetical Protein YBL036C are shown. This protein, P007, was selected by the structural genomics approach described at http://proteome.bnl.gov Though the protein has no sequence similarity with previously known structures it folds as a TIM-barrel. The cofactor pyridoxal-5'-phosphate is covalently bound to the protein in the active site. Cofactor and interacting residues are shown in ball and stick representation. from: Eswaramoorthy S, Gerchman S, Graziano V, Kycia H, Studier FW, and Swaminathan S. Structure of a yeast hypothetical protein selected by a structural genomics approach. Acta Cryst. D59(1): 127-35 (2003).   Medline Abstract   PDB files 1B54, 1CT5