Stefan Tafrov

Biology Department, 463
Brookhaven National Laboratory
Upton, NY 11973-5000

tel: (631) 344-3605
fax: (631) 344-3407
tafrov@bnl.gov

The Group:
Stefan Tafrov 344-3605

Research Interests:

Understanding the molecular organization of the chromatin and the changes in it during replication, transcription, silencing, repair etc.
Development of models for examining the effects of the radiation over human skin cells.
Molecular biology of the yeast Saccharamyces.

References:
Bennett P.V., Cuomo N.L., Paul S., Tafrov S.T., and Sutherland B.M.
Endogenous DNA damage clusters in human skin, 3-D model, and cultured skin cells.
Free Radical Biol. Med., 39(6):832-839 (2005).  PubMed
Poveda A., Pamblanco M., Tafrov S., Tordera V., Sternglanz R. and Sendra R.
Hif1 is a component of yeast histone acetyltransferase B, a complex mainly localizedin the nucleus.
J. Biol. Chem., 279(16):16033-16043 (2004).  PubMed
John S., Howe L., Tafrov S.T., Grant P.A., Sternglanz R. and Workman J.L.
The something about silencing protein, Sas3, is the catalytic subunit of NuA3, a yTAF(II)30-containing HAT complex that interacts with the Spt16 subunit of the yeast CP (Cdc68/Pob3)-FACT complex.
Genes Dev., 14(10):1196-1208 (2000). PubMed
Landry J., Sutton A., Tafrov S.T., Heller R.C., Stebbins J., Pillus L. and Sternglanz R.
The silencing protein SIR2 and its homologs are NAD-dependent protein deacetylases.
Proc. Natl. Acad. Sci. USA, 97(11):5807-5811 (2000).  PubMed
Angus-Hill M.L., Dutnall R.N., Tafrov S.T., Sternglanz R. and Ramakrishnan V.
Crystal structure of the histone acetyltransferase Hpa2: A tetrameric member of the Gcn5-related N-acetyltransferase superfamily.
J. Mol. Biol., 294(5):1311-1325 (1999). PubMed
Dutnall R.N., Tafrov S.T., Sternglanz R. and Ramakrishnan V.
Structure of the yeast histone acetyltransferase Hat1: Insights into substrate specificity and implications for the Gcn5-related N-acetyltransferase superfamily.
Cold Spring Harbor Symp. Quant. Biol., 63:501-507, Review (1998). PubMed
Dutnal R.N., Tafrov S.T., Sternglanz R., Ramakrishnan V.
Structure of the histone acetyltransferase Hat1: A paradigm for the GCN5-related N-acetyltransferase superfamily.
Cell, 94(4):427-438 (1998). PubMed
Tafrov S., Chakarov S. and Venkov P.
Localization of EEN1 gene on chromosome II of the yeast Saccharomyces cerevisiae.
Proc. Bulgarian Acad. Sci., 46:121-123 (1993).
Tafrov S. and Venkov P.
Saccharomyces cerevisiae mutants sensitive to sodium dodecyl sulphate.
Proc. Bulgarian Acad. Sci., 45:119-121 (1992).
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